Catecholamines Agonists

Catecholamines Agonists

 Catecholamines Agonists :

Epinephrine
A and B receptors -  B1, A1, B2

- Good for emergency bronchospasm treatment (acute asthma or anaphylactic shock) and open-angle glaucoma
-  Also gives longer duration of anesthetic action via vasocontriction and reducing systemic absorption
- Increases sBP lowers dBP

Norepinephrine
- A and B in therapeutic doses, most A receptor influence
- Good to increase peripheral resistance (A1)
- Good for shock treatment (increase TPR and BP); increases sBP and dBP

Isoproterenol
- Synthetic: B1 and B2, little A stimulation
- Strong cardiac stimulation (b1), dilation of skeletal vessels (b2), and bronchodilation (b2)
- Increases sBP lowers dBP


Dopamine
 - Precursor to NE; A and B activity and dopamine receptors in renal and mesenteric vasculature causing vasodilation
- B1 stimulation of the heart
- Therapeutic: choice drug for shock as it increases BP via cardiac stimulation and also increases kidney blood flow (increased GFR and Na  diuresis)

Dobutamine
- Synthetic B1 agonist
- To increase CO in CHF
- Watch out in Afib as it may increase AV conduction

Phenylephrine - Synthetic A1 agonist – for nasal decongestion

Methoxamine - Synthetic A1 agonist – for hTN in surgery

Clonidine - A2 agonist- - Used to lower pressure in essential HTN (via CNS effect, diminishing sympathetic outflow)

Related Questions Autonomic nervous system

 Catecholamines Agonists :

Epinephrine
A and B receptors -  B1, A1, B2

- Good for emergency bronchospasm treatment (acute asthma or anaphylactic shock) and open-angle glaucoma
-  Also gives longer duration of anesthetic action via vasocontriction and reducing systemic absorption
- Increases sBP lowers dBP

Norepinephrine
- A and B in therapeutic doses, most A receptor influence
- Good to increase peripheral resistance (A1)
- Good for shock treatment (increase TPR and BP); increases sBP and dBP

Isoproterenol
- Synthetic: B1 and B2, little A stimulation
- Strong cardiac stimulation (b1), dilation of skeletal vessels (b2), and bronchodilation (b2)
- Increases sBP lowers dBP


Dopamine
 - Precursor to NE; A and B activity and dopamine receptors in renal and mesenteric vasculature causing vasodilation
- B1 stimulation of the heart
- Therapeutic: choice drug for shock as it increases BP via cardiac stimulation and also increases kidney blood flow (increased GFR and Na  diuresis)

Dobutamine
- Synthetic B1 agonist
- To increase CO in CHF
- Watch out in Afib as it may increase AV conduction

Phenylephrine - Synthetic A1 agonist – for nasal decongestion

Methoxamine - Synthetic A1 agonist – for hTN in surgery

Clonidine - A2 agonist- - Used to lower pressure in essential HTN (via CNS effect, diminishing sympathetic outflow)